The group led by M-ller use this research method of develop chemicals up to pre-scientific testing. In this task, the Mainz group will primarily concentrate on substances that may be utilized for prophylaxis and/or therapy of osteoporosis aswell as on fresh antimicrobial peptides and substances with neuroprotective activity. M-ller and his research group have previously demonstrated that bioactive chemicals could be synthesized through the use of recombinant molecular biology methods. They were in a position to demonstrate that defensin, a toxin and defense peptide made by sponges, is bioactive if stated in a recombinant method.Related StoriesRXi Pharmaceuticals starts Phase 1/2 clinical trial in ophthalmologyAstellas enters into definitive agreement to acquire OcataAmgen's IMLYGIC receives positive opinion from CHMP for treatment of melanomaOne of the methods along the way of inflammation following connection with LPS is a profuse production of type 1 interferons. These proteins play a significant function in the regulation of immunity. The Ghent experts administered 10 moments the lethal dose of LPS to the mutant mice, without deadly implications. This finding cannot be attributed to an alteration in TLR4, but to a reduced production of type 1 interferons. To verify this, Mahieu and her colleagues administered these interferons preventatively to the mice – which made the animals susceptible to LPS once again.