An increased respiratory rate and/or airway swelling may bring about dynamic gas and hyperinflation trapping. Appropriate administration of exacerbations contains the use of bronchodilators, systemic corticosteroids, antibiotics and, in severe exacerbations, non-invasive positive pressure ventilation. Patients who have had one exacerbation are likely to have got a recurrence highly. A proper follow-up management program and early initiation of therapy might improve outcomes..Researchers divided sufferers into three groups, each given the placebo, 5 mg clazosentan or 15 mg clazosentan. They halted CONSCIOUS-3 prematurely after sufferers in CONSCIOUS-2 , which ran concurrently, showed no take advantage of the drug. In CONSCIOUS-3, 27 % of sufferers on placebo died, had vasospasm-related blood clots or neurological complications, or acquired rescue therapy to treat vasospasm, weighed against 24 % in the 5 mg/h and 15 % in the 15 mg/h clazosentan groups. The chances of the combined endpoint had been 53 % lower at the higher clazosentan dose than with a placebo. Despite having less than half of the intended individuals in the study, we were motivated to see that at a high dose there was a substantial reduction in vasospasm in individuals in the beginning treated with endovascular coiling, Macdonald said.