Crizotinib inhibits the enzyme, so that the cancer cells to die.. In some patients with non-small cell lung cancer , the anaplastic lymphoma kinase gene may move and fuse with another gene Thisng fusion produces an enzyme that promotes cancer cell growth. This fusion happens in about four % of NSCLC patients. The chances of a patient increases with the fusion, when they have the adenocarcinoma subtype of lung cancer or Non smoking or former light smokers , and other features.
The new drug, crizotinib, under development by Pfizer, showed dramatic results in reducing lung cancer tumors in some patients during Phase I and II clinical trials. – ‘The results of the first two studies are very encouraging,’said Lyudmila Bazhenova, assistant professor of clinical professor at UC San Diego School of Medicine and member of the Moores UCSD Cancer Center. ‘The Phase III trials will be critical to determine whether this drug goes to market. ‘.. New Lung Cancer Drug shows dramatic results for shrinking tumorspatients with a certain type of lung cancer may benefit from a Phase III trial of the Moores UCSD Cancer Center.Over Alfacell socialAlfacell Inc. Be a biopharmaceutical company of discovery, development and market innovative therapeutics for cancer, by means their proprietary ribonuclease technology platforms. Onconase , Alfacell the leading investigational product candidate is currently analyzed III b in multiple studies, including one -stage trial for malignant mesothelioma and a Phase I / II trial in non-small cell lung cancer . For more info you can visit.
A 20 percent onconase Non – Small Cell Lung Cancer DataAlfacell Corporation today announced that Intae Lee, Department of Radiology, University of Pennsylvania in, presenting new data on effectiveness to the onconase from non-small cell lung in the 14 Annual Meeting of the International Society for Magnetic Resonance in Medicine , 6-12 May in Seattle, WA place. Presenting presentation shall be entitled Ranpirnase – induced blood flow changes, lactate and ATP levels of into A549 human NSCLC out of Not – invasive near infrared – Red spectroscopic and Magnetic Resonance Spectroscopy as measured.