Forcing them to pause and take stock.

‘A whole lot of improvement has been manufactured in understanding the molecular details of checkpoint activation,’ says senior author Tony Hunter, Ph.D., a professor in the Molecular and Cell Biology Laboratory, ‘but checkpoint termination, which is essential for the resumption of cell routine progression, is less well understood.’ The Salk researchers say that a better understanding of this crucial procedure may allow them to develop biological markers that predict medical resistance to chemotherapy also to design cancer drugs with fewer unwanted effects by exploiting the molecular mechanism underlying the checkpoint exit.Kesler’s team used human brain scans and a series of simple cognitive duties to evaluate neurological function in 44 breast malignancy patients, 25 of whom had undergone chemotherapy, and 18 healthy women. The researchers found that whether they experienced gotten chemo, breasts cancer patients had abnormally low levels of activity in human brain regions involved with high-level mental function. However the ability to perform the jobs was affected just in those that had gotten chemo.