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Researchers from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the instances of 5,715 patients with septic shock to look for the appropriateness of preliminary antimicrobial therapy, clinical infection site, and relevant pathogens. Results showed that inappropriate initial antimicrobial therapy occurred in 20 % of individuals, and the entire survival was 43.7 %. Survival after inappropriate and appropriate preliminary therapy was 52 % and 10.3 %, respectively. Furthermore, the reduction in survival with inappropriate preliminary therapy ranged from 2.3-fold for pneumococcal infection to 17.6-fold with primary bacteremia. Experts conclude that efforts to increase the rate of recurrence of appropriateness of preliminary antimicrobial therapy must be central to attempts to reduce mortality from septic shock.