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Brucellosis Treatment The cornerstone of treatment for brucellosis is antibiotics. Due to the high relapse rate linked to the disease, the use of a multidrug antibiotic regimen is preferred. The antimicrobials mostly used include doxycycline , streptomycin, rifampin , gentamicin , and trimethoprim-sulfamethoxazole . The combination of antibiotics used will change based on disease severity, pregnancy and age.