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Blastomycosis Signs and Symptoms Fortunately, about 50 percent of most people infected with the fungi usually do not show any observeable symptoms of blastomycosis. When symptoms of blastomycosis do take place, they show up after a latent or incubation time period that ranges from around three to 15 weeks following the initial contact with the fungi. However, the original symptoms of blastomycosis resemble flu symptoms . If blastomycosis is pass on by the bloodstream or lymphatic system, epidermis bone or lesions lesions might develop. Picture of skin damage because of blastomycosis; SOURCE: CDC.